Drug interactions
Itraconazole + Umeclidinium-vilanterol
Severity: Moderate
Itraconazole and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and raises systemic vilanterol exposure, which can amplify beta-agonist cardiovascular effects such as tachycardia, palpitations, tremor and hypokalemia. Itraconazole itself can prolong the QT interval. The risk is greatest in patients with cardiac disease.
What this interaction means in plain words
Itraconazole and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4 and P-gp-mediated clearance increases vilanterol exposure, with additive QT effects.
What to do
Use with caution and monitor for tachycardia, tremor, hypokalemia and QT prolongation, with an ECG in patients at cardiac risk. Consider an alternative antifungal or a different bronchodilator if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Itraconazole and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is a strong CYP3A4 inhibitor and raises systemic vilanterol exposure, which can amplify beta-agonist cardiovascular effects such as tachycardia, palpitations, tremor and hypokalemia. Itraconazole itself can prolong the QT interval. The risk is greatest in patients with cardiac disease.
How serious is the interaction between Itraconazole and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use with caution and monitor for tachycardia, tremor, hypokalemia and QT prolongation, with an ECG in patients at cardiac risk. Consider an alternative antifungal or a different bronchodilator if cardiovascular effects occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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