Drug interactions
Itraconazole + Vardenafil
Severity: Major
Itraconazole and Vardenafil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is a strong CYP3A4 inhibitor and markedly increases vardenafil exposure, raising the risk of hypotension, priapism and QT prolongation. Itraconazole itself can affect cardiac repolarization. Labeling restricts the vardenafil dose with strong CYP3A4 inhibitors.
What this interaction means in plain words
Itraconazole and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Vardenafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated vardenafil metabolism, plus additive QT effects.
What to do
Avoid the combination where possible. If used, follow labeling with a markedly reduced vardenafil dose and longer dosing interval, and consider ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Itraconazole with Vardenafil?
MediHelp rates the interaction as major. Itraconazole and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole is a strong CYP3A4 inhibitor and markedly increases vardenafil exposure, raising the risk of hypotension, priapism and QT prolongation. Itraconazole itself can affect cardiac repolarization. Labeling restricts the vardenafil dose with strong CYP3A4 inhibitors.
How serious is the interaction between Itraconazole and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, follow labeling with a markedly reduced vardenafil dose and longer dosing interval, and consider ECG monitoring.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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