Drug interactions
Itraconazole + Vonoprazan
Severity: Moderate
Itraconazole and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan raises gastric pH profoundly, which reduces the dissolution and absorption of itraconazole capsules. This may lead to subtherapeutic antifungal levels and treatment failure. Itraconazole solution and SUBA formulations are less dependent on acid.
What this interaction means in plain words
Itraconazole and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acidity decreases dissolution and absorption of acid-dependent itraconazole capsules.
What to do
Avoid itraconazole capsules with vonoprazan or switch to the oral solution. Consider measuring itraconazole trough levels and monitoring clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Itraconazole and Vonoprazan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Itraconazole with Vonoprazan?
MediHelp rates the interaction as moderate. Itraconazole and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan raises gastric pH profoundly, which reduces the dissolution and absorption of itraconazole capsules. This may lead to subtherapeutic antifungal levels and treatment failure. Itraconazole solution and SUBA formulations are less dependent on acid.
How serious is the interaction between Itraconazole and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid itraconazole capsules with vonoprazan or switch to the oral solution. Consider measuring itraconazole trough levels and monitoring clinical response.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
