Drug interactions
Itraconazole + Voxelotor
Severity: Moderate
Itraconazole and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor is a CYP3A4 inhibitor and may raise itraconazole exposure. Voxelotor itself is a CYP3A4 substrate, and itraconazole may also increase voxelotor levels.
What this interaction means in plain words
Itraconazole and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Voxelotor belongs to Miscellaneous.
Why it happens
Bidirectional CYP3A4 inhibition affecting both drugs' clearance.
What to do
Reduce the voxelotor dose per labeling when a strong CYP3A4 inhibitor is needed. Monitor for itraconazole toxicity, including liver function and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Itraconazole with Voxelotor?
MediHelp rates the interaction as moderate. Itraconazole and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor is a CYP3A4 inhibitor and may raise itraconazole exposure. Voxelotor itself is a CYP3A4 substrate, and itraconazole may also increase voxelotor levels.
How serious is the interaction between Itraconazole and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the voxelotor dose per labeling when a strong CYP3A4 inhibitor is needed. Monitor for itraconazole toxicity, including liver function and ECG.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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