Drug interactions
Itraconazole + Voxilaprevir
Severity: Moderate
Itraconazole and Voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase voxilaprevir plasma concentrations. Higher exposure could raise the likelihood of adverse effects such as gastrointestinal upset and headache.
What this interaction means in plain words
Itraconazole and Voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Voxilaprevir belongs to Anti Virals.
Why it happens
Itraconazole inhibits CYP3A4 (and transporters such as P-gp), which contribute to voxilaprevir clearance.
What to do
Monitor for adverse effects of the hepatitis C regimen when starting or stopping itraconazole. No empiric dose change is needed in most patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Voxilaprevir
- Apalutamide + Voxilaprevir Contraindicated
- Phenytoin + Voxilaprevir Contraindicated
- Bosentan + Voxilaprevir Major
- Carbamazepine + Voxilaprevir Major
- Efavirenz + Voxilaprevir Major
- Enzalutamide + Voxilaprevir Major
Frequently asked questions
Can I take Itraconazole with Voxilaprevir?
MediHelp rates the interaction as moderate. Itraconazole and Voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase voxilaprevir plasma concentrations. Higher exposure could raise the likelihood of adverse effects such as gastrointestinal upset and headache.
How serious is the interaction between Itraconazole and Voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the hepatitis C regimen when starting or stopping itraconazole. No empiric dose change is needed in most patients.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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