Drug interactions
Ivabradine + Nadolol
Severity: Moderate
Ivabradine and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivabradine and the beta-blocker nadolol both lower heart rate, so bradycardia and heart block risk is increased. This combination is common in heart failure and angina, but it needs heart rate surveillance.
What this interaction means in plain words
Ivabradine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivabradine belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive heart rate reduction via sinus node If current inhibition and beta-adrenergic blockade.
What to do
Monitor heart rate and blood pressure during initiation and titration. Reduce or stop ivabradine if resting heart rate falls below about 50 beats per minute or symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Nadolol
Frequently asked questions
Can I take Ivabradine with Nadolol?
MediHelp rates the interaction as moderate. Ivabradine and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivabradine and the beta-blocker nadolol both lower heart rate, so bradycardia and heart block risk is increased. This combination is common in heart failure and angina, but it needs heart rate surveillance.
How serious is the interaction between Ivabradine and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure during initiation and titration. Reduce or stop ivabradine if resting heart rate falls below about 50 beats per minute or symptoms occur.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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