Drug interactions
Ivabradine + Sertraline
Severity: Minor
Ivabradine and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is generally a weak inhibitor of CYP3A4, so any rise in ivabradine exposure is expected to be small. The legacy concern assumes moderate inhibition, which does not reflect sertraline's usual profile. Clinical significance is limited, though both agents can influence heart rate.
What this interaction means in plain words
Ivabradine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivabradine belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline may slightly raise ivabradine concentrations.
What to do
No dose change is normally needed; monitor heart rate for bradycardia when starting or increasing sertraline in patients on ivabradine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Ivabradine with Sertraline?
MediHelp rates the interaction as minor. Ivabradine and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline is generally a weak inhibitor of CYP3A4, so any rise in ivabradine exposure is expected to be small. The legacy concern assumes moderate inhibition, which does not reflect sertraline's usual profile. Clinical significance is limited, though both agents can influence heart rate.
How serious is the interaction between Ivabradine and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor heart rate for bradycardia when starting or increasing sertraline in patients on ivabradine.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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