Drug interactions
Ivabradine + Ticagrelor
Severity: Minor
Ivabradine and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor, so any increase in ivabradine exposure is likely modest. It is not a moderate inhibitor of the kind that ivabradine labeling advises avoiding. Ticagrelor itself can cause bradyarrhythmias and ventricular pauses, which may add to ivabradine's effect on heart rate.
What this interaction means in plain words
Ivabradine and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivabradine belongs to Cardiovascular; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ticagrelor may marginally raise ivabradine levels, with possible additive bradycardia.
What to do
No dose adjustment is usually needed; monitor heart rate and symptoms of bradycardia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivabradine
- Atazanavir + Ivabradine Contraindicated
- Clarithromycin + Ivabradine Contraindicated
- Cobicistat + Ivabradine Contraindicated
- Conivaptan + Ivabradine Contraindicated
- Darunavir + Ivabradine Contraindicated
- Diltiazem + Ivabradine Contraindicated
Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Ivabradine with Ticagrelor?
MediHelp rates the interaction as minor. Ivabradine and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A4 inhibitor, so any increase in ivabradine exposure is likely modest. It is not a moderate inhibitor of the kind that ivabradine labeling advises avoiding. Ticagrelor itself can cause bradyarrhythmias and ventricular pauses, which may add to ivabradine's effect on heart rate.
How serious is the interaction between Ivabradine and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor heart rate and symptoms of bradycardia.
What other medicines interact with Ivabradine?
MediHelp also lists interactions of Ivabradine with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Ivabradine page.
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