Drug interactions
ivabradine + verapamil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Excess bradycardia; avoid.
Mechanism of action
CYP3A4-mediated ↑ ivabradine + AV node effects.
Clinical management
Avoid; choose alternative rate control.
Drug reference
References
Frequently asked questions
Can I take ivabradine with verapamil?
The interaction is rated: Major. Excess bradycardia; avoid.
How serious is the interaction between ivabradine and verapamil?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ivabradine and verapamil managed?
Avoid; choose alternative rate control.
Why do ivabradine and verapamil interact?
CYP3A4-mediated ↑ ivabradine + AV node effects.
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