Drug interactions
Ivacaftor + Methoxsalen
Severity: Moderate
Ivacaftor and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A4 substrate, and methoxsalen may inhibit CYP3A4 and increase its exposure. Higher levels could raise adverse effects such as transaminase elevation and headache.
What this interaction means in plain words
Ivacaftor and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Methoxsalen belongs to Anti Fungals.
Why it happens
Possible CYP3A4 inhibition by methoxsalen reducing ivacaftor clearance.
What to do
Monitor liver function and tolerability, and reduce the ivacaftor dose if a CYP3A4 inhibitor effect is confirmed or adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Methoxsalen?
MediHelp rates the interaction as moderate. Ivacaftor and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor is a CYP3A4 substrate, and methoxsalen may inhibit CYP3A4 and increase its exposure. Higher levels could raise adverse effects such as transaminase elevation and headache.
How serious is the interaction between Ivacaftor and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function and tolerability, and reduce the ivacaftor dose if a CYP3A4 inhibitor effect is confirmed or adverse effects occur.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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