Drug interactions
Ivacaftor + Mifepristone
Severity: Moderate
Ivacaftor and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can increase ivacaftor exposure by inhibiting CYP3A4. Higher levels may increase adverse effects such as liver enzyme elevations and headache.
What this interaction means in plain words
Ivacaftor and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated ivacaftor metabolism by mifepristone.
What to do
Reduce the ivacaftor dose according to the product labeling for strong CYP3A inhibitors. Monitor liver function tests.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Mifepristone?
MediHelp rates the interaction as moderate. Ivacaftor and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone can increase ivacaftor exposure by inhibiting CYP3A4. Higher levels may increase adverse effects such as liver enzyme elevations and headache.
How serious is the interaction between Ivacaftor and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ivacaftor dose according to the product labeling for strong CYP3A inhibitors. Monitor liver function tests.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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