Drug interactions
Ivacaftor + Orphenadrin
Severity: Minor
Ivacaftor and Orphenadrin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor is a CYP3A4 substrate, but orphenadrine is not an established clinically relevant CYP3A4 inhibitor. Any increase in ivacaftor exposure is likely small.
What this interaction means in plain words
Ivacaftor and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Orphenadrin belongs to Musculoskeletal.
Why it happens
Possible weak CYP3A4 inhibition; not clearly established.
What to do
No routine dose change is needed; monitor for ivacaftor adverse effects such as elevated liver enzymes and headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Orphenadrin
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Orphenadrin?
MediHelp rates the interaction as minor. Ivacaftor and Orphenadrin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor is a CYP3A4 substrate, but orphenadrine is not an established clinically relevant CYP3A4 inhibitor. Any increase in ivacaftor exposure is likely small.
How serious is the interaction between Ivacaftor and Orphenadrin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for ivacaftor adverse effects such as elevated liver enzymes and headache.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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