Drug interactions
Ivacaftor + Paclitaxel
Severity: Moderate
Ivacaftor and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and could increase systemic paclitaxel exposure. The clinical effect is unconfirmed but relevant given paclitaxel's narrow therapeutic index.
What this interaction means in plain words
Ivacaftor and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Paclitaxel belongs to Oncology.
Why it happens
P-glycoprotein inhibition by ivacaftor may reduce paclitaxel efflux and clearance.
What to do
Monitor blood counts and neuropathy and lower the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Paclitaxel?
MediHelp rates the interaction as moderate. Ivacaftor and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and could increase systemic paclitaxel exposure. The clinical effect is unconfirmed but relevant given paclitaxel's narrow therapeutic index.
How serious is the interaction between Ivacaftor and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy and lower the paclitaxel dose if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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