Drug interactions
Ivacaftor + Saxagliptin-metformin
Severity: Minor
Ivacaftor and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and could modestly increase saxagliptin exposure. Saxagliptin has a wide therapeutic margin so clinical impact is expected to be small.
What this interaction means in plain words
Ivacaftor and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Weak inhibition of P-glycoprotein efflux, increasing saxagliptin absorption.
What to do
No dose change is generally required; monitor glucose and adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Ivacaftor and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-glycoprotein and could modestly increase saxagliptin exposure. Saxagliptin has a wide therapeutic margin so clinical impact is expected to be small.
How serious is the interaction between Ivacaftor and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor glucose and adverse effects.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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