Drug interactions
Ivacaftor + Sitagliptin
Severity: Minor
Ivacaftor and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite can inhibit intestinal and renal P-glycoprotein, which may modestly raise sitagliptin exposure. Sitagliptin has a wide therapeutic margin, so a clinically significant effect is not expected in most patients.
What this interaction means in plain words
Ivacaftor and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivacaftor belongs to Miscellaneous; Sitagliptin belongs to Endocrine.
Why it happens
Weak inhibition of P-glycoprotein efflux of sitagliptin by ivacaftor.
What to do
No dose change is usually needed. Monitor for sitagliptin adverse effects such as GI upset or hypoglycemia if combined with sulfonylureas or insulin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Ivacaftor with Sitagliptin?
MediHelp rates the interaction as minor. Ivacaftor and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor and its M1 metabolite can inhibit intestinal and renal P-glycoprotein, which may modestly raise sitagliptin exposure. Sitagliptin has a wide therapeutic margin, so a clinically significant effect is not expected in most patients.
How serious is the interaction between Ivacaftor and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for sitagliptin adverse effects such as GI upset or hypoglycemia if combined with sulfonylureas or insulin.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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