Drug interactions
Ivacaftor + Warfarin
Severity: Moderate
Ivacaftor and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor may alter warfarin exposure and thus anticoagulant effect, so INR can change after starting or stopping it.
What this interaction means in plain words
Ivacaftor and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivacaftor belongs to Miscellaneous; Warfarin belongs to Cardiovascular.
Why it happens
Ivacaftor weakly inhibits CYP2C9 and P-glycoprotein, which may change warfarin exposure.
What to do
Monitor INR more frequently when starting, changing or stopping ivacaftor and adjust the warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Ivacaftor with Warfarin?
MediHelp rates the interaction as moderate. Ivacaftor and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor may alter warfarin exposure and thus anticoagulant effect, so INR can change after starting or stopping it.
How serious is the interaction between Ivacaftor and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently when starting, changing or stopping ivacaftor and adjust the warfarin dose accordingly.
What other medicines interact with Ivacaftor?
MediHelp also lists interactions of Ivacaftor with, for example, Ensitrelvir, Apalutamide, Carbamazepine. The full list is on the Ivacaftor page.
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