Drug interactions
Ivosidenib + Lacosamide
Severity: Minor
Ivosidenib and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces some CYP enzymes, but lacosamide is not primarily dependent on CYP2C9 and has several elimination routes. A meaningful loss of lacosamide effect is unlikely.
What this interaction means in plain words
Ivosidenib and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Lacosamide belongs to Central Nervous System.
Why it happens
Possible weak enzyme induction by ivosidenib affecting minor lacosamide metabolic pathways.
What to do
No dose change is generally needed. Monitor seizure control if ivosidenib is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Lacosamide?
MediHelp rates the interaction as minor. Ivosidenib and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces some CYP enzymes, but lacosamide is not primarily dependent on CYP2C9 and has several elimination routes. A meaningful loss of lacosamide effect is unlikely.
How serious is the interaction between Ivosidenib and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor seizure control if ivosidenib is started.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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