Drug interactions
Ivosidenib + Linagliptin
Severity: Moderate
Ivosidenib and Linagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower linagliptin exposure. Because induction by strong inducers like rifampin lowers linagliptin levels and effect, a similar but smaller effect is possible.
What this interaction means in plain words
Ivosidenib and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Linagliptin belongs to Endocrine.
Why it happens
CYP3A4 and possibly P-gp induction by ivosidenib increases linagliptin clearance.
What to do
Monitor glycemic control and consider adding or switching therapy if it worsens. Reassess after ivosidenib is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Linagliptin?
MediHelp rates the interaction as moderate. Ivosidenib and Linagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower linagliptin exposure. Because induction by strong inducers like rifampin lowers linagliptin levels and effect, a similar but smaller effect is possible.
How serious is the interaction between Ivosidenib and Linagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and consider adding or switching therapy if it worsens. Reassess after ivosidenib is discontinued.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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