Drug interactions
Ivosidenib + Modafinil
Severity: Moderate
Ivosidenib and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower modafinil exposure, which could reduce wakefulness-promoting effect. The effect is generally modest and clinically manageable.
What this interaction means in plain words
Ivosidenib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Modafinil belongs to Central Nervous System.
Why it happens
Ivosidenib induces CYP3A4, increasing the partial CYP3A4-mediated clearance of modafinil.
What to do
Monitor for reduced modafinil efficacy and increase the dose if needed. Reassess the dose if ivosidenib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Modafinil?
MediHelp rates the interaction as moderate. Ivosidenib and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower modafinil exposure, which could reduce wakefulness-promoting effect. The effect is generally modest and clinically manageable.
How serious is the interaction between Ivosidenib and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced modafinil efficacy and increase the dose if needed. Reassess the dose if ivosidenib is stopped.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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