Drug interactions
Ivosidenib + Ranolazine
Severity: Major
Ivosidenib and Ranolazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QTc interval and so does ranolazine, so the combination may raise arrhythmia risk. Ivosidenib also induces CYP3A4, which may lower ranolazine concentrations and reduce antianginal effect.
What this interaction means in plain words
Ivosidenib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
Additive QT prolongation plus CYP3A4 induction by ivosidenib reducing ranolazine exposure.
What to do
Avoid the combination where possible and use an alternative antianginal. If unavoidable, monitor ECG and electrolytes and assess angina control.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Ranolazine?
MediHelp rates the interaction as major. Ivosidenib and Ranolazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QTc interval and so does ranolazine, so the combination may raise arrhythmia risk. Ivosidenib also induces CYP3A4, which may lower ranolazine concentrations and reduce antianginal effect.
How serious is the interaction between Ivosidenib and Ranolazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antianginal. If unavoidable, monitor ECG and electrolytes and assess angina control.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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