Drug interactions
Ivosidenib + Risperidone
Severity: Major
Ivosidenib and Risperidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QT interval, and risperidone adds to this effect. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Ivosidenib and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Avoid if possible, or choose an alternative antipsychotic. If unavoidable, monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Risperidone?
MediHelp rates the interaction as major. Ivosidenib and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib can prolong the QT interval, and risperidone adds to this effect. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Ivosidenib and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or choose an alternative antipsychotic. If unavoidable, monitor ECG and electrolytes frequently.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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