Drug interactions
Ivosidenib + Ropivacaine
Severity: Minor
Ivosidenib and Ropivacaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4, which could modestly lower ropivacaine levels. Because CYP1A2 is the main pathway, the clinical effect is expected to be small.
What this interaction means in plain words
Ivosidenib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ivosidenib belongs to Oncology; Ropivacaine belongs to Central Nervous System.
Why it happens
Ivosidenib induces CYP3A4, increasing a secondary clearance pathway of ropivacaine.
What to do
No adjustment is routinely needed; assess anesthetic efficacy and re-dose per clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Ropivacaine?
MediHelp rates the interaction as minor. Ivosidenib and Ropivacaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivosidenib induces CYP3A4, which could modestly lower ropivacaine levels. Because CYP1A2 is the main pathway, the clinical effect is expected to be small.
How serious is the interaction between Ivosidenib and Ropivacaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is routinely needed; assess anesthetic efficacy and re-dose per clinical response.
What other medicines interact with Ropivacaine?
MediHelp also lists interactions of Ropivacaine with, for example, Bupivacaine implant, Bupivacaine liposome, Amlodipine-benazepril. The full list is on the Ropivacaine page.
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