Drug interactions
Ivosidenib + Ruxolitinib
Severity: Moderate
Ivosidenib and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer, so it is more likely to lower ruxolitinib exposure than raise it, possibly reducing efficacy. Ivosidenib is also a substrate of CYP3A4, but the net effect on ruxolitinib has not been studied.
What this interaction means in plain words
Ivosidenib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Ruxolitinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by ivosidenib may increase ruxolitinib metabolism.
What to do
Monitor for reduced ruxolitinib response such as spleen size or symptom control. Adjust the ruxolitinib dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ruxolitinib
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Ruxolitinib?
MediHelp rates the interaction as moderate. Ivosidenib and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer, so it is more likely to lower ruxolitinib exposure than raise it, possibly reducing efficacy. Ivosidenib is also a substrate of CYP3A4, but the net effect on ruxolitinib has not been studied.
How serious is the interaction between Ivosidenib and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced ruxolitinib response such as spleen size or symptom control. Adjust the ruxolitinib dose if efficacy declines.
What other medicines interact with Ruxolitinib?
MediHelp also lists interactions of Ruxolitinib with, for example, Atazanavir, Ceritinib, Chloramphenicol. The full list is on the Ruxolitinib page.
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