Drug interactions
Ivosidenib + Sevoflurane
Severity: Major
Ivosidenib and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib prolongs the QT interval, and sevoflurane has similar effects. The combination may increase the risk of torsades de pointes. The legacy wording describing a decrease in QTc is inaccurate, since both drugs lengthen it.
What this interaction means in plain words
Ivosidenib and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG continuously perioperatively, and discuss with the oncology team whether ivosidenib needs to be interrupted.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Sevoflurane?
MediHelp rates the interaction as major. Ivosidenib and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib prolongs the QT interval, and sevoflurane has similar effects. The combination may increase the risk of torsades de pointes. The legacy wording describing a decrease in QTc is inaccurate, since both drugs lengthen it.
How serious is the interaction between Ivosidenib and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium before anesthesia. Monitor the ECG continuously perioperatively, and discuss with the oncology team whether ivosidenib needs to be interrupted.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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