Drug interactions
Ivosidenib + Sotalol
Severity: Major
Ivosidenib and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can prolong the QT interval, and combined use with sotalol may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances or bradycardia.
What this interaction means in plain words
Ivosidenib and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ivosidenib belongs to Oncology; Sotalol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Replace one agent if possible; if both are needed, monitor ECG and electrolytes frequently and correct potassium and magnesium. Hold or reduce ivosidenib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Sotalol?
MediHelp rates the interaction as major. Ivosidenib and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ivosidenib can prolong the QT interval, and combined use with sotalol may increase the risk of torsades de pointes. The risk is greater with electrolyte disturbances or bradycardia.
How serious is the interaction between Ivosidenib and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Replace one agent if possible; if both are needed, monitor ECG and electrolytes frequently and correct potassium and magnesium. Hold or reduce ivosidenib if QTc becomes markedly prolonged.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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