Drug interactions
Ivosidenib + Trazodone
Severity: Moderate
Ivosidenib and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer that may lower trazodone exposure and reduce its efficacy. Ivosidenib also prolongs the QT interval, adding to trazodone's own QT effect.
What this interaction means in plain words
Ivosidenib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases trazodone clearance; additive QT prolongation is also possible.
What to do
Monitor the clinical response to trazodone and adjust the dose if needed. Obtain ECG and electrolytes at baseline and periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Trazodone?
MediHelp rates the interaction as moderate. Ivosidenib and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer that may lower trazodone exposure and reduce its efficacy. Ivosidenib also prolongs the QT interval, adding to trazodone's own QT effect.
How serious is the interaction between Ivosidenib and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the clinical response to trazodone and adjust the dose if needed. Obtain ECG and electrolytes at baseline and periodically.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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