Drug interactions
Ivosidenib + Zonisamide
Severity: Moderate
Ivosidenib and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower zonisamide concentrations, since CYP3A4 contributes to its metabolism. This could reduce seizure control.
What this interaction means in plain words
Ivosidenib and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ivosidenib belongs to Oncology; Zonisamide belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 by ivosidenib increases zonisamide clearance.
What to do
Monitor seizure frequency and consider zonisamide serum levels. Increase the zonisamide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Ivosidenib with Zonisamide?
MediHelp rates the interaction as moderate. Ivosidenib and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower zonisamide concentrations, since CYP3A4 contributes to its metabolism. This could reduce seizure control.
How serious is the interaction between Ivosidenib and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and consider zonisamide serum levels. Increase the zonisamide dose if control worsens.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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