Drug interactions
Ixabepilone + Posaconazole
Severity: Major
Ixabepilone and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may markedly increase ixabepilone exposure, raising the risk of neutropenia, peripheral neuropathy and other severe toxicity. Labeling advises avoiding strong CYP3A4 inhibitors with ixabepilone.
What this interaction means in plain words
Ixabepilone and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Posaconazole inhibits CYP3A4, the main enzyme metabolizing ixabepilone.
What to do
Avoid the combination and use a non-CYP3A4-inhibiting antifungal if possible. If unavoidable, reduce the ixabepilone dose per labeling and monitor blood counts and neuropathy closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Ixabepilone with Posaconazole?
MediHelp rates the interaction as major. Ixabepilone and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole may markedly increase ixabepilone exposure, raising the risk of neutropenia, peripheral neuropathy and other severe toxicity. Labeling advises avoiding strong CYP3A4 inhibitors with ixabepilone.
How serious is the interaction between Ixabepilone and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-inhibiting antifungal if possible. If unavoidable, reduce the ixabepilone dose per labeling and monitor blood counts and neuropathy closely.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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