Drug interactions
Ixazomib + Larotrectinib
Severity: Minor
Ixazomib and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a weak CYP3A4 inhibitor and could slightly raise ixazomib concentrations. Given ixazomib's low sensitivity to CYP3A inhibition, a meaningful effect is unlikely.
What this interaction means in plain words
Ixazomib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Larotrectinib belongs to Oncology.
Why it happens
Larotrectinib weakly inhibits CYP3A4, which may slightly reduce ixazomib metabolism.
What to do
No dose change is needed; monitor for ixazomib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Larotrectinib
Frequently asked questions
Can I take Ixazomib with Larotrectinib?
MediHelp rates the interaction as minor. Ixazomib and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a weak CYP3A4 inhibitor and could slightly raise ixazomib concentrations. Given ixazomib's low sensitivity to CYP3A inhibition, a meaningful effect is unlikely.
How serious is the interaction between Ixazomib and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor for ixazomib adverse effects.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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