Drug interactions
Ixazomib + Lorlatinib
Severity: Minor
Ixazomib and Lorlatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A inducer and could reduce ixazomib exposure, potentially diminishing efficacy. The clinical significance is uncertain, since ixazomib is cleared by several pathways at lower concentrations.
What this interaction means in plain words
Ixazomib and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ixazomib belongs to Oncology; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing ixazomib metabolism.
What to do
No routine dose change; monitor myeloma response and be aware of possible reduced ixazomib effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Ixazomib with Lorlatinib?
MediHelp rates the interaction as minor. Ixazomib and Lorlatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lorlatinib is a moderate CYP3A inducer and could reduce ixazomib exposure, potentially diminishing efficacy. The clinical significance is uncertain, since ixazomib is cleared by several pathways at lower concentrations.
How serious is the interaction between Ixazomib and Lorlatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor myeloma response and be aware of possible reduced ixazomib effect.
What other medicines interact with Ixazomib?
MediHelp also lists interactions of Ixazomib with, for example, Apalutamide, Carbamazepine, Dabrafenib. The full list is on the Ixazomib page.
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