Drug interactions
Ixazomib + Oxcarbazepine
Severity: Moderate
Ixazomib and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce ixazomib exposure through CYP3A induction. Strong inducers markedly lowered ixazomib exposure, and a lesser effect is expected with oxcarbazepine, with possible loss of efficacy.
What this interaction means in plain words
Ixazomib and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ixazomib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction by oxcarbazepine accelerates the metabolism of ixazomib.
What to do
Prefer a non-inducing antiseizure drug. If oxcarbazepine is required, monitor disease response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Ixazomib
- Apalutamide + Ixazomib Major
- Carbamazepine + Ixazomib Major
- Dabrafenib + Ixazomib Major
- Enzalutamide + Ixazomib Major
- Etrasimod + Ixazomib Major
- Fosphenytoin + Ixazomib Major
Frequently asked questions
Can I take Ixazomib with Oxcarbazepine?
MediHelp rates the interaction as moderate. Ixazomib and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce ixazomib exposure through CYP3A induction. Strong inducers markedly lowered ixazomib exposure, and a lesser effect is expected with oxcarbazepine, with possible loss of efficacy.
How serious is the interaction between Ixazomib and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug. If oxcarbazepine is required, monitor disease response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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