Drug interactions
Japanese encephalitis virus vaccine + Lomustine
Severity: Moderate
Japanese encephalitis virus vaccine and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine immunosuppression may reduce the antibody response to inactivated Japanese encephalitis vaccine, which matters for travelers at risk.
What this interaction means in plain words
Japanese encephalitis virus vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocytes and bone marrow reduces vaccine-induced immune response.
What to do
Complete the series at least 2 weeks before lomustine when possible; otherwise check immunity or revaccinate after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Japanese encephalitis virus vaccine with Lomustine?
MediHelp rates the interaction as moderate. Japanese encephalitis virus vaccine and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine immunosuppression may reduce the antibody response to inactivated Japanese encephalitis vaccine, which matters for travelers at risk.
How serious is the interaction between Japanese encephalitis virus vaccine and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the series at least 2 weeks before lomustine when possible; otherwise check immunity or revaccinate after immune recovery.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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