Drug interactions
Ketamine + Liothyronine
Severity: Moderate
Ketamine and Liothyronine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormone increases sympathetic sensitivity, and ketamine has sympathomimetic effects. Together they can cause marked hypertension and tachycardia, particularly in patients with cardiac disease.
What this interaction means in plain words
Ketamine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Liothyronine belongs to Endocrine.
Why it happens
Additive sympathetic stimulation, with thyroid hormone enhancing adrenergic responsiveness to ketamine.
What to do
Monitor blood pressure and heart rate during ketamine use in patients on liothyronine. Be cautious in those with coronary disease or uncontrolled hyperthyroid state.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Liothyronine?
MediHelp rates the interaction as moderate. Ketamine and Liothyronine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormone increases sympathetic sensitivity, and ketamine has sympathomimetic effects. Together they can cause marked hypertension and tachycardia, particularly in patients with cardiac disease.
How serious is the interaction between Ketamine and Liothyronine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during ketamine use in patients on liothyronine. Be cautious in those with coronary disease or uncontrolled hyperthyroid state.
What other medicines interact with Liothyronine?
MediHelp also lists interactions of Liothyronine with, for example, Alogliptin-metformin, Amitriptyline, Amobarbital. The full list is on the Liothyronine page.
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