Drug interactions
Ketamine + Metoclopramide
Severity: Minor
Ketamine and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on the CNS and may add to sedation, dizziness and psychomotor impairment. Ketamine can also cause hypertension and agitation, and metoclopramide may cause restlessness.
What this interaction means in plain words
Ketamine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketamine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS effects; no established pharmacokinetic interaction.
What to do
Monitor sedation level and for agitation or restlessness. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Metoclopramide?
MediHelp rates the interaction as minor. Ketamine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs act on the CNS and may add to sedation, dizziness and psychomotor impairment. Ketamine can also cause hypertension and agitation, and metoclopramide may cause restlessness.
How serious is the interaction between Ketamine and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and for agitation or restlessness. No dose change is usually needed.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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