Drug interactions
Ketamine + Nitisinone
Severity: Minor
Ketamine and Nitisinone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitisinone inhibits CYP2C9, which contributes only a minor part to ketamine metabolism, so any increase in ketamine exposure is expected to be small. Clinically meaningful effects are unlikely.
What this interaction means in plain words
Ketamine and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketamine belongs to Central Nervous System; Nitisinone belongs to Miscellaneous.
Why it happens
Weak inhibition of CYP2C9 by nitisinone with a minor effect on ketamine clearance.
What to do
No routine adjustment is needed. Be aware of possible prolonged sedation when giving ketamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Nitisinone
- Adefovir + Nitisinone Moderate
- Bosentan + Nitisinone Moderate
- Celecoxib + Nitisinone Moderate
- Chlorpropamide + Nitisinone Moderate
- Diclofenac + Nitisinone Moderate
- Fluvastatin + Nitisinone Moderate
Frequently asked questions
Can I take Ketamine with Nitisinone?
MediHelp rates the interaction as minor. Ketamine and Nitisinone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitisinone inhibits CYP2C9, which contributes only a minor part to ketamine metabolism, so any increase in ketamine exposure is expected to be small. Clinically meaningful effects are unlikely.
How serious is the interaction between Ketamine and Nitisinone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Be aware of possible prolonged sedation when giving ketamine.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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