Drug interactions
Ketamine + Posaconazole
Severity: Moderate
Ketamine and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can raise ketamine exposure because ketamine is partly cleared by CYP3A4. Higher levels may deepen sedation, prolong recovery and increase cardiovascular stimulation or psychotomimetic effects.
What this interaction means in plain words
Ketamine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4-mediated N-demethylation of ketamine, reducing its clearance.
What to do
Titrate ketamine to clinical effect using the lowest effective dose and monitor sedation depth, blood pressure and heart rate. Allow for a longer recovery period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Posaconazole?
MediHelp rates the interaction as moderate. Ketamine and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can raise ketamine exposure because ketamine is partly cleared by CYP3A4. Higher levels may deepen sedation, prolong recovery and increase cardiovascular stimulation or psychotomimetic effects.
How serious is the interaction between Ketamine and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to clinical effect using the lowest effective dose and monitor sedation depth, blood pressure and heart rate. Allow for a longer recovery period.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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