Drug interactions
Ketamine + Prochlorperazine
Severity: Moderate
Ketamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they may deepen sedation and prolong recovery. Phenothiazines may also add to hypotension and can lower the seizure threshold.
What this interaction means in plain words
Ketamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with additive hypotensive effects of phenothiazine alpha blockade.
What to do
Titrate ketamine to effect and monitor level of consciousness, blood pressure and respiration. Reduce doses in older or debilitated patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Ketamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they may deepen sedation and prolong recovery. Phenothiazines may also add to hypotension and can lower the seizure threshold.
How serious is the interaction between Ketamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect and monitor level of consciousness, blood pressure and respiration. Reduce doses in older or debilitated patients.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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