Drug interactions
Ketamine + Tucatinib
Severity: Moderate
Ketamine and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A4 and can raise ketamine exposure, since ketamine is partly cleared by this enzyme. Higher levels may cause deeper sedation, dissociation, hypertension and tachycardia.
What this interaction means in plain words
Ketamine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4-mediated metabolism of ketamine, reducing its clearance.
What to do
Titrate ketamine to effect using the lowest effective dose and monitor hemodynamics, sedation depth and emergence reactions. Reduce the ketamine dose if exaggerated effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Ketamine with Tucatinib?
MediHelp rates the interaction as moderate. Ketamine and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A4 and can raise ketamine exposure, since ketamine is partly cleared by this enzyme. Higher levels may cause deeper sedation, dissociation, hypertension and tachycardia.
How serious is the interaction between Ketamine and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect using the lowest effective dose and monitor hemodynamics, sedation depth and emergence reactions. Reduce the ketamine dose if exaggerated effects occur.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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