Drug interactions
Ketoconazole + Linagliptin
Severity: Minor
Ketoconazole and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole modestly raises linagliptin exposure. Because linagliptin has a wide therapeutic margin and is mainly eliminated unchanged, the clinical effect is usually small.
What this interaction means in plain words
Ketoconazole and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Linagliptin belongs to Endocrine.
Why it happens
Ketoconazole inhibits CYP3A4 and P-glycoprotein, which have a minor role in linagliptin clearance.
What to do
No dose adjustment is generally needed; monitor glycemic control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Ketoconazole with Linagliptin?
MediHelp rates the interaction as minor. Ketoconazole and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole modestly raises linagliptin exposure. Because linagliptin has a wide therapeutic margin and is mainly eliminated unchanged, the clinical effect is usually small.
How serious is the interaction between Ketoconazole and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor glycemic control as usual.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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