Drug interactions
Ketoconazole + Modafinil
Severity: Minor
Ketoconazole and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise modafinil concentrations, possibly increasing insomnia, anxiety, headache or cardiovascular effects. The effect is expected to be modest.
What this interaction means in plain words
Ketoconazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Modafinil belongs to Central Nervous System.
Why it happens
Ketoconazole inhibits CYP3A4, a secondary pathway of modafinil metabolism.
What to do
Monitor for increased adverse effects such as agitation, palpitations or insomnia and lower the modafinil dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Modafinil
Frequently asked questions
Can I take Ketoconazole with Modafinil?
MediHelp rates the interaction as minor. Ketoconazole and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may raise modafinil concentrations, possibly increasing insomnia, anxiety, headache or cardiovascular effects. The effect is expected to be modest.
How serious is the interaction between Ketoconazole and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects such as agitation, palpitations or insomnia and lower the modafinil dose if needed.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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