Drug interactions
Ketoconazole + Mometasone
Severity: Moderate
Ketoconazole and Mometasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole strongly inhibits CYP3A4 and can raise systemic exposure to mometasone. This may cause systemic corticosteroid effects, including adrenal suppression, with prolonged use.
What this interaction means in plain words
Ketoconazole and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Mometasone belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of mometasone increases systemic levels.
What to do
Monitor for Cushingoid features and adrenal suppression during extended co-use. Consider an alternative inhaled steroid or dose reduction if long-term ketoconazole is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mometasone
- Mometasone + Ritonavir Major
- Atazanavir + Mometasone Moderate
- Clarithromycin + Mometasone Moderate
- Cobicistat + Mometasone Moderate
- Darunavir + Mometasone Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Mometasone Moderate
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Mometasone?
MediHelp rates the interaction as moderate. Ketoconazole and Mometasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole strongly inhibits CYP3A4 and can raise systemic exposure to mometasone. This may cause systemic corticosteroid effects, including adrenal suppression, with prolonged use.
How serious is the interaction between Ketoconazole and Mometasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression during extended co-use. Consider an alternative inhaled steroid or dose reduction if long-term ketoconazole is required.
What other medicines interact with Mometasone?
MediHelp also lists interactions of Mometasone with, for example, Ritonavir, Atazanavir, Clarithromycin. The full list is on the Mometasone page.
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