Drug interactions
Ketoconazole + Omaveloxolone
Severity: Major
Ketoconazole and Omaveloxolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole, a strong CYP3A4 inhibitor, raises omaveloxolone plasma exposure. This may increase dose-related adverse effects such as liver enzyme elevation and other toxicities.
What this interaction means in plain words
Ketoconazole and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketoconazole belongs to Anti Fungals; Omaveloxolone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of omaveloxolone in the liver and gut wall.
What to do
Avoid the combination where possible; if it cannot be avoided, reduce the omaveloxolone dose as directed in labeling and monitor liver tests and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Ketoconazole with Omaveloxolone?
MediHelp rates the interaction as major. Ketoconazole and Omaveloxolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole, a strong CYP3A4 inhibitor, raises omaveloxolone plasma exposure. This may increase dose-related adverse effects such as liver enzyme elevation and other toxicities.
How serious is the interaction between Ketoconazole and Omaveloxolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it cannot be avoided, reduce the omaveloxolone dose as directed in labeling and monitor liver tests and tolerability.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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