Drug interactions
ketoconazole + oxycodone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ oxycodone → overdose risk.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Avoid or reduce dose; monitor respiratory status.
Drug reference
References
Frequently asked questions
Can I take ketoconazole with oxycodone?
The interaction is rated: Major. ↑ oxycodone → overdose risk.
How serious is the interaction between ketoconazole and oxycodone?
The interaction is rated: Major. Evidence level: High.
How is the interaction between ketoconazole and oxycodone managed?
Avoid or reduce dose; monitor respiratory status.
Why do ketoconazole and oxycodone interact?
CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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