Drug interactions
Ketoconazole + Ozanimod
Severity: Moderate
Ketoconazole and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise exposure to the active metabolites of ozanimod, which could increase the risk of adverse effects such as bradyarrhythmia, hepatic injury and infections. The clinical effect is not well characterized.
What this interaction means in plain words
Ketoconazole and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Ozanimod belongs to Central Nervous System.
Why it happens
Possible inhibition of BCRP-mediated efflux of ozanimod active metabolites; the contribution is not firmly established.
What to do
Monitor heart rate, liver tests and signs of adverse effects when the drugs are combined, and consider an alternative antifungal if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ketoconazole with Ozanimod?
MediHelp rates the interaction as moderate. Ketoconazole and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may raise exposure to the active metabolites of ozanimod, which could increase the risk of adverse effects such as bradyarrhythmia, hepatic injury and infections. The clinical effect is not well characterized.
How serious is the interaction between Ketoconazole and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, liver tests and signs of adverse effects when the drugs are combined, and consider an alternative antifungal if toxicity appears.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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