Drug interactions
Ketoconazole + Ruxolitinib
Severity: Moderate
Ketoconazole and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases ruxolitinib exposure, which can intensify cytopenias such as thrombocytopenia and neutropenia.
What this interaction means in plain words
Ketoconazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Ruxolitinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces ruxolitinib clearance.
What to do
Reduce the ruxolitinib dose as directed by labeling for strong CYP3A4 inhibitors. Monitor blood counts frequently and adjust the dose by response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Ketoconazole with Ruxolitinib?
MediHelp rates the interaction as moderate. Ketoconazole and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole increases ruxolitinib exposure, which can intensify cytopenias such as thrombocytopenia and neutropenia.
How serious is the interaction between Ketoconazole and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ruxolitinib dose as directed by labeling for strong CYP3A4 inhibitors. Monitor blood counts frequently and adjust the dose by response.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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