Drug interactions
Ketoconazole + Stiripentol
Severity: Moderate
Ketoconazole and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may raise stiripentol concentrations, which could increase sedation, ataxia and other central nervous system effects. Stiripentol is metabolized by several CYP enzymes, so the magnitude is uncertain.
What this interaction means in plain words
Ketoconazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Stiripentol belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP3A4-mediated metabolism of stiripentol, which has multiple clearance pathways.
What to do
Monitor for sedation, ataxia and other adverse effects, and reduce the stiripentol dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Ketoconazole with Stiripentol?
MediHelp rates the interaction as moderate. Ketoconazole and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole may raise stiripentol concentrations, which could increase sedation, ataxia and other central nervous system effects. Stiripentol is metabolized by several CYP enzymes, so the magnitude is uncertain.
How serious is the interaction between Ketoconazole and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia and other adverse effects, and reduce the stiripentol dose if toxicity occurs.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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