Drug interactions
Ketoprofen + Labetalol
Severity: Moderate
Ketoprofen and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged NSAID use can blunt the blood pressure-lowering effect of beta-blockers such as labetalol. The effect is usually modest but can reduce blood pressure control.
What this interaction means in plain words
Ketoprofen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Labetalol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and sodium and fluid retention oppose the antihypertensive action.
What to do
Monitor blood pressure during sustained ketoprofen use and adjust antihypertensive therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Ketoprofen with Labetalol?
MediHelp rates the interaction as moderate. Ketoprofen and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged NSAID use can blunt the blood pressure-lowering effect of beta-blockers such as labetalol. The effect is usually modest but can reduce blood pressure control.
How serious is the interaction between Ketoprofen and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during sustained ketoprofen use and adjust antihypertensive therapy as required.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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