Drug interactions
Ketoprofen + Levomilnacipran
Severity: Moderate
Ketoprofen and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SNRIs impair platelet serotonin uptake and aggregation, and combined with an NSAID this increases the risk of bleeding, particularly upper gastrointestinal bleeding. The risk is higher in older adults and those with ulcer history.
What this interaction means in plain words
Ketoprofen and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function (serotonin depletion plus COX-1 inhibition) with NSAID mucosal injury.
What to do
Monitor for GI bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients; avoid long-term concurrent use if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Ketoprofen with Levomilnacipran?
MediHelp rates the interaction as moderate. Ketoprofen and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SNRIs impair platelet serotonin uptake and aggregation, and combined with an NSAID this increases the risk of bleeding, particularly upper gastrointestinal bleeding. The risk is higher in older adults and those with ulcer history.
How serious is the interaction between Ketoprofen and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients; avoid long-term concurrent use if possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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