Drug interactions
Ketoprofen + Losartan
Severity: Moderate
Ketoprofen and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of losartan and, together, may cause acute kidney injury and hyperkalemia. Risk is greatest in older, dehydrated patients or those with existing renal impairment.
What this interaction means in plain words
Ketoprofen and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Losartan belongs to Cardiovascular.
Why it happens
NSAID blockade of prostaglandin-mediated afferent arteriolar dilation combined with ARB efferent dilation reduces glomerular filtration and promotes sodium retention and potassium retention.
What to do
Monitor blood pressure, serum creatinine and potassium within the first weeks of combined use and keep the patient hydrated. Avoid the combination in volume depletion or advanced renal disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ketoprofen and Losartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Ketoprofen with Losartan?
MediHelp rates the interaction as moderate. Ketoprofen and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of losartan and, together, may cause acute kidney injury and hyperkalemia. Risk is greatest in older, dehydrated patients or those with existing renal impairment.
How serious is the interaction between Ketoprofen and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium within the first weeks of combined use and keep the patient hydrated. Avoid the combination in volume depletion or advanced renal disease.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
