Drug interactions
Ketoprofen + Moxifloxacin
Severity: Moderate
Ketoprofen and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAID use may increase the seizure-provoking potential of fluoroquinolones, although the absolute risk is low. Patients with epilepsy or other CNS risk factors are most vulnerable.
What this interaction means in plain words
Ketoprofen and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone inhibition of GABA binding may be potentiated by NSAIDs; mechanism not fully established.
What to do
Avoid in patients with seizure disorders; otherwise monitor for CNS stimulation and discontinue moxifloxacin if seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Ketoprofen with Moxifloxacin?
MediHelp rates the interaction as moderate. Ketoprofen and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAID use may increase the seizure-provoking potential of fluoroquinolones, although the absolute risk is low. Patients with epilepsy or other CNS risk factors are most vulnerable.
How serious is the interaction between Ketoprofen and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders; otherwise monitor for CNS stimulation and discontinue moxifloxacin if seizures occur.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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